Investigation of Genetic Polymorphism of Drug Metabolism in Canadian Inuit
Regions: Qikiqtaaluk Region, Nunavut
Tags: health, health care, biology, genetics, ethnicity
| Principal Investigator: | Rode, Andris (4) |
| Licence Number: | 12757 |
| Organization: | Health and Welfare Canada |
| Licensed Year(s): |
1995
|
| Issued: | Jan 01, 1995 |
| Project Team: | Dr. P. Vloshinsky, Dr. M. Jurima-Romet |
Objective(s): To identify interethnic differences in drug metabolism in order to enable effective drug regulation and risk-benefit management.
Project Description: The study requires the subject to swallow a harmless "marker" substance (similar to cough syrup) at bedtime, followed by the collection of subject's total urine output over the next 8-12 hours. The urine will be analysed to see how well the subject's body metabolised or used the marker and whether the subject is a "good" or "poor" drug metaboliser. Blood samples will be taken to determine the genetic differences between good and poor metabolisers.
