Molecular analysis of evolutionary change in stickleback populations
chercheur principal: Kingsley, David M. (4)
Nᵒ de permis: 13308
Organisation: Stanford University
Année(s) de permis: 2010 2008 2007 2005 2004 2002 2001 2000
Délivré: mai 12, 2002
Équipe de projet: Michael Sh

Objectif(s): We are interested in the genetic and molecular basis of evolutionary change in animal form. Our goal is to determine whether the same genes control similar skeletal change in different populations and species. Stickleback fish are ideal subjects for this study because different freshwater populations show morphological differences in skeletal structures. Variation in the pelvic spines may be the most striking of these differences: some populations of the ninespine stickleback, brook stickleback and threespine stickleback have large pelvic spines, while others have none at all. In order to test whether these similar skeletal changes also have a similar genetic basis, we are collecting sticklebacks with reduced pelvic spines and crossing them in the laboratory with sticklebacks with complete spines. This procedure allows us to map and eventually identify the genes responsible for skeletal differences between populations. Fox Holes Lake is unique because it is one of the few sites in the world containing ninespine and brook sticklebacks with complete reduction of the pelvic spines. Thus, laboratory crosses using fish from this lake will allow us to map the genes responsible for evolutionary change in these exceptional populations.